Protein Extrusion and Postprandial Amino Acid Handling (BABE)

University of Exeter

Status: Completed

Conditions: Postprandial Plasma Amino Acid Availability

Treatments: Dietary Supplement: Dry protein blend ingestion; Dietary Supplement: Extruded protein blend ingestion

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT05584358

21-10-20-A-06 v2

Details and patient eligibility

About

The bulk of research that has investigated the effect of dietary protein on muscle tissue in humans has used isolated, minimally processed protein powders. However, the protein that we consume on a daily basis has typically undergone various processing methods, and evidence suggests these can change the way our bodies metabolise the protein. 'Extrusion' is a common processing method that uses high pressure to produce protein containing cereals and meat replacement foods. There is currently no research looking at how extrusion affects the way a protein source is digested and absorbed in humans. This study will compare the availability of ingested protein in the blood in the hours following consumption of an extruded versus a non-extruded source.

Enrollment: 9 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI between 18 and 30.
• Metabolically healthy

Exclusion criteria

• Any metabolic impairments
• cardio/pulmonary diseases.
• Chronic use of the over the counter medicine
• A personal or family history of epilepsy, seizures or schizophrenia.
• Allergic to mycoprotein/Quorn/edible fungi/environmental mould products.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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9 participants in 2 patient groups

Dry Blend

Experimental group

Description:

A dry blend of mycoprotein and pea protein.

Treatment:

Dietary Supplement: Dry protein blend ingestion

Extrudate

Experimental group

Description:

An extruded blend of mycoprotein and pea protein

Treatment:

Dietary Supplement: Extruded protein blend ingestion