Protein Ingestion and Muscle Carnitine Uptake

University of Nottingham

Status and phase: Completed; Phase 1

Conditions: Muscle, Skeletal

Treatments: Dietary Supplement: Flavoured water; Dietary Supplement: Flavoured water + carbohydrate + protein; Dietary Supplement: Flavoured water + carbohydrate

Study type: Interventional

Funder types: Other

Identifiers

NCT02535897

G26062012 BMS

Details and patient eligibility

About

The purpose of this study is to assess the effects of a protein-carbohydrate beverage on the absorption of an orally ingested bolus of L-carnitine, compared to flavoured water and carbohydrate-only controls, and to determine whether increasing plasma carnitine availability can impact upon insulin-stimulated muscle carnitine uptake.

Enrollment: 7 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• Body mass index of 18-25 kg/cm2

Exclusion criteria

• Unhealthy
• Smoker
• Taking any medication that interferes with skeletal muscle metabolism

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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7 participants in 3 patient groups, including a placebo group

CON

Placebo Comparator group

Description:

500 ml of flavoured water

Treatment:

Dietary Supplement: Flavoured water

CHO

Active Comparator group

Description:

500 ml of flavoured water containing 80 g carbohydrate

Treatment:

Dietary Supplement: Flavoured water + carbohydrate

CHO-PRO

Active Comparator group

Description:

500 ml of flavoured water containing 40 g carbohydrate and 40 g whey protein

Treatment:

Dietary Supplement: Flavoured water + carbohydrate + protein