Protein Ingestion and Skeletal Muscle Atrophy

University of Exeter

Status: Completed

Conditions: Muscle Atrophy

Treatments: Other: Lower limb immobilisation (leg brace) with varying levels of protein intake

Study type: Interventional

Funder types: Other

Identifiers

NCT03797781

6500619582

Details and patient eligibility

About

The effect of different protein intakes on skeletal muscle atrophy during short term unilateral leg immobilisation.

Enrollment: 33 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI >18 and <28 no prescription medications or current illness.

Exclusion criteria

• BMI <18 and >28 current prescription medication no history of leg injury.
• Smoker
• Medical conditions including (cardiovascular disease ((e.g. hypertension)), metabolic disease ((e.g. type 2 diabetes)), any personal or family history of deep vein thrombosis.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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33 participants in 3 patient groups

High protein

Experimental group

Treatment:

Other: Lower limb immobilisation (leg brace) with varying levels of protein intake

Low protein

Experimental group

Treatment:

Other: Lower limb immobilisation (leg brace) with varying levels of protein intake

Minimum protein

Experimental group

Treatment:

Other: Lower limb immobilisation (leg brace) with varying levels of protein intake