Protein Intake on Muscle Protein Synthesis Overnight

Nestlé

Status and phase

Completed

Phase 1

Conditions

Protein Synthesis Overnight

Treatments

Dietary Supplement: Placebo

Dietary Supplement: Milk protein

Study type

Interventional

Funder types

Industry

Identifiers

NCT02041143

13.19.MET

Details and patient eligibility

About

This trial is an exploratory study in order to determine whether the ingestion of one type of protein (milk protein/CHO/Fat) vs.placebo (CHO/Fat) 2 hours before bed time results in the extension of the post-prandial window of anabolism during the night by increasing whole body protein balance as well as muscle protein fractional synthesis rate (FSR).

Enrollment

17 patients

Sex

Male

Ages

55 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Male
Healthy as determined by the medical questionnaire and the medical visit including blood sampling
55-65y of age
BMI (19.0 - 25.0 kg/ m²)
Having signed the consent form

Exclusion criteria

Digestive (intestinal, gastric, hepatic or pancreatic), renal or metabolic disease, as determined by the medical (screening) visit and a blood chemistry analysis (glucose, total cholesterol, LDL, HDL, triglycerides, aspartate transaminase, alanine aminotransferase, gamma glutamyl transpeptidase, C Reactive Protein, creatinin)
Heart or other organ disease
Arterial hypertension (Systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg)
Any clotting trouble (diagnosed by Prothrombin time (PT), activated Partial Thromboplastin Time (aPTT), fibrinogen measures and platelets number (the latter is part of a classical blood cells counting at screening)
Any inflammatory disease in the past four weeks
Use of specific medications
Recent major surgery (3 months)
History of major gastro-intestinal surgery (gastric bypass, intestinal resection etc...)
History of cancer within the past year
Significant weight loss during the last 3 months (5% and more)
Food allergies, especially cow milk protein allergies
Special diets especially vegetarian, high protein or weight loss program (anamnesis)
Smokers
High level structured exercise 3 times a week (e.g.: fitness club, competitions...)
Have a high alcohol consumption (more than 2 drinks/day)
Consumption of illicit drugs anamnesis only
Having given blood within the last month, or willing to make a blood donation until one month following the end of the study
Subject who cannot be expected to comply with the study procedures, including consuming the test products.
Currently participating or having participated in another clinical trial during the last month prior to the beginning of this study