Protein Kinase N1 Level in Patients Undergoing Cardiac Surgery

Zhongnan Hospital

Status: Completed

Conditions: Surgery; Acute Kidney Injury; Extracorporeal Circulation; Complications

Treatments: Other: PKN1 level

Study type: Observational

Funder types: Other

Identifiers

NCT05386940

2017004

Details and patient eligibility

About

Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as well as heath care expenditure. Identification of relevant biomarkers may lead to early diagnosis and improve patient outcomes and health care costs. The pathophysiology of CSA-AKI is complex and ischemia-reperfusion injury is one of the important factors. Recently, it has been shown that Protein kinase N1 (PKN1) is associated with ischemia-reperfusion injury. In this study, relationship between PKN1 with the risk of CSA-AKI was analyzed and the predictive value of elevated level of PKN1 for early prediction of CSA-AKI was further evaluated.

Full description

Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. The incidence of cardiac surgery-associated AKI (CSA-AKI) varies from 5% to 42% and is the second leading cause of AKI (after sepsis) in the intensive care unit (ICU). CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as well as heath care expenditure. Early detection of CSA-AKI could improve patient outcomes and health care costs through targeted interventions. Thus, identification of relevant biomarkers may lead to early diagnosis. The pathophysiology of CSA-AKI is complex and ischemia-reperfusion injury is one of the important factors. Recently, it has been shown that Protein kinase N1 (PKN1) is associated with ischemia-reperfusion injury. Nowadays, little is known about relationship between PKN1 and CSA-AKI. In this study, relationship between PKN1 with the risk of CSA-AKI was analyzed and the predictive value of elevated level of PKN1 for early prediction of CSA-AKI was further evaluated.

Enrollment: 110 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients (≥18 years old) underwent on-pump cardiac surgery
• admitted to ICU immediately after surgery

Exclusion criteria

• Patients younger than 18 years
• with prior AKI
• end-stage kidney disease
• need for chronic hemodialysis
• pregnant patients
• unable to give written consent for participation

Trial design

110 participants in 3 patient groups

PKN1 Tertile 1

Treatment:

Other: PKN1 level

PKN1 Tertile 2

Treatment:

Other: PKN1 level

PKN1 Tertile 3

Treatment:

Other: PKN1 level