Protein Nutrition for Muscle Hypertrophy in Older Adults

Nestlé

Status: Completed

Conditions: Healthy Elderly Muscle; Anabolically Resistant Elderly Muscle

Treatments: Dietary Supplement: glycine; Dietary Supplement: isolated whey protein; Dietary Supplement: micellar whey protein; Dietary Supplement: citrulline

Study type: Interventional

Funder types: Industry

Identifiers

NCT02315391

11.06.NRC

Details and patient eligibility

About

The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly.

Full description

The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly

Enrollment: 30 patients

Sex: Male

Ages: 65 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Must habitually complete a minimum of 5000 steps per day
• Having obtained informed consent
• Non-obese
• Non-smoker

Exclusion criteria

• Aged >80 years
• Inability to comply with study procedures
• Currently participating or having participated in another infusion trial during last 12 months
• Any acute or chronic llness
• History of neuromuscular problems
• Medications known to affect protein metabolism
• Individuals who complete fewer than 5000 steps per day
• Individuals who have metal implants

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 3 patient groups

20g isolated whey protein + 30g carb, 8,5g fat, 15g glycine

Experimental group

Description:

20g isolated whey protein + 30g carb, 8,5g fat, 15g glycine

Treatment:

Dietary Supplement: isolated whey protein

Dietary Supplement: glycine

20g micellar whey protein + 30g carb, 8.5g fat, 15g glycine

Experimental group

Description:

20g micellar whey protein + 30g carb, 8.5g fat, 15g glycine

Treatment:

Dietary Supplement: glycine

Dietary Supplement: micellar whey protein

20g micellar whey protein + 30g carb, 8.5g fat, 5g citrulline

Experimental group

Description:

20g micellar whey protein + 30g carb, 8.5g fat, 5g citrulline

Treatment:

Dietary Supplement: citrulline

Dietary Supplement: micellar whey protein