Protein Supplementation and Exercise Training in Burn Patients

Cairo University (CU)

Status: Completed

Conditions: Burns

Treatments: Dietary Supplement: whey protein supplementation powder (Inkospor X-TREME; France); Other: traditional burn care; Other: Exercise training program

Study type: Interventional

Funder types: Other

Identifiers

NCT04508218

P.T.REC/012/002758

Details and patient eligibility

About

Burn injury causes continuous catabolism of the skeletal muscle resulting in decreased muscle strength, muscle mass and impairment of functional mobility. Purpose: The purpose of this study is to investigate the efficacy of combination of exercise training and protein supplementation on lean body mass (LBM) and muscle strength in patients with severe burn.

Full description

Sixty participants with severe burn > 30% total body surface area (TBSA) were randomly distributed into 4 equal groups of 15 participants per group. Group A (Protein+ Exercise group) received oral protein supplementation, exercise program and traditional burn care, group B (Protein group) received oral protein supplementation and traditional burn care, group C (Exercise group) received exercise program and traditional burn care, group D (Control group) received traditional burn care. LBM was measured using Dual-energy x-ray absorptiometry (DXA) while muscle strength was measured using Biodex 3 Dynamometer System before treatment and 12 weeks after treatment.

Enrollment: 60 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healed deep partial-thickness thermal burn
• > 30% of TBSA and
• the exercise program started after healing of the burn (after burn injury by 6 weeks)

Exclusion criteria

• conditions that may affect on participation in the exercise program as a recent coronary disease, uncontrolled hypertension, orthopedic problems limiting exercise, abnormal cardiac stress test, pregnant women, refusal to participate in a physical activity program,
• presence of psychological or cognitive disorders (aggressive behavior, impulsivity, dementia)
• food intolerance to milk protein products.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 4 patient groups

Protein+ Exercise group

Experimental group

Description:

Received oral protein supplementation, exercise program and traditional burn care

Treatment:

Other: traditional burn care

Other: Exercise training program

Dietary Supplement: whey protein supplementation powder (Inkospor X-TREME; France)

Protein group

Experimental group

Description:

Received oral protein supplementation and traditional burn care

Treatment:

Other: traditional burn care

Dietary Supplement: whey protein supplementation powder (Inkospor X-TREME; France)

Exercise group

Experimental group

Description:

Received exercise program and traditional burn care

Treatment:

Other: traditional burn care

Other: Exercise training program

Control group

Other group

Description:

Received traditional burn care

Treatment:

Other: traditional burn care