Protein Supply in Elderly

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Muscle Synthesis

Treatments: Dietary Supplement: Protein

Study type: Interventional

Funder types: Other

Identifiers

NCT01317511

MEC 09-3-078.3

Details and patient eligibility

About

Stimulating overnight muscle protein synthesis, might augment muscle hypertrophy, increase mitochondrial mass, and/or improve muscle tissue repair. The goal of this proposal will be to provide further insight into the responsiveness of the muscle protein synthetic machinery to food intake in relation to age.

Enrollment: 16 patients

Sex: Male

Ages: 65 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Males
• Age between 65 and 80 years
• BMI < 30 kg/m2

Exclusion criteria

• Type 2 diabetic patients
• Use of medication
• All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. artrosis, arthritis, spasticity/rigidity, all neurological disorders and paralysis).
• Use of anticoagulants, blood diseases, allergy for lidocain.
• Contra indications for the use of a nasogastric tube: high risk of aspiration, gastric stasis, gastro-oesophageal reflux, upper gastrointestinal stricture, nasal injuries and base of skull fractures.
• Patients suffering from PKU (Phenylketonuria).

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

16 participants in 2 patient groups, including a placebo group

Protein

Experimental group

Description:

Protein drink

Treatment:

Dietary Supplement: Protein

Placebo

Placebo Comparator group

Description:

water

Treatment:

Dietary Supplement: Protein