Proteins From Duckweed Trial (ProDuckT)

Wageningen University and Research

Status: Completed

Conditions: Degree of Digestilbility

Treatments: Dietary Supplement: Duckweed protein; Dietary Supplement: Whey protein

Study type: Interventional

Funder types: Other

Identifiers

NCT03823222

NL66859.081.18

Details and patient eligibility

About

This study aims to study the digestibility of isolated duckweed protein. The digestibility of the isolated duckweed protein will be compared to an isolated benchmark protein whey.

Objective: The primary objective is to investigate the digestibility of isolated duckweed protein and the isolated benchmark protein whey.

Study design: The study is a cross-over, double blind, controlled trial in which study participants will visit the research facility on two occasions under fasting conditions. Subjects will receive two protein sources in randomized order with a washout period of one week. Blood will be collected via a catheter before and up-to 3 hours after protein consumption.

Study population: We aim to include 12 healthy volunteers aged 18-50 years. Intervention: Study participants will receive 20 grams of isolated duckweed protein and the isolated benchmark protein whey.

Main study parameters/endpoints: The main study parameter is blood amino acids measured before and after consumption of 20 g protein.

Enrollment: 12 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body mass index (BMI) between 18 and 25 kg/m2
• Having veins suitable for blood sampling via a catheter (judged by study nurse/ medical doctor)

Exclusion criteria

• Any metabolic, gastrointestinal, inflammatory or chronic disease (such as diabetes, anaemia, hepatitis, cardiovascular disease)
• History of gastro-intestinal surgery or having (serious) gastro-intestinal complaints
• History of liver dysfunction (cirrhosis, hepatitis) or liver surgery
• Kidney dysfunction (self-reported)
• Use of medication that may influence the study results, such as gastric acid inhibitors, laxatives, stomach protectors and drugs that can affect intestinal motility
• Anaemia (Hb values <7.5 for women and <8.5 for men)
• Reported slimming, medically prescribed, vegan/vegetarian or other extreme diets or the use of protein supplements
• Not willing to give up blood donation during the study
• Current smokers
• Alcohol intake ≥4 glasses of alcoholic beverages per day
• Pregnant, lactating or wishing to become pregnant in the period of the study (self-reported)
• Abuse of illicit drugs
• Food allergies for products that we use in the study
• Participation in another clinical trial at the same time
• Being an employee of the department Consumer Science & Health group of Wageningen Food & Biobased Research

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 2 patient groups

Duckweed protein

Experimental group

Description:

20 gram of isolated protein

Treatment:

Dietary Supplement: Duckweed protein

Whey protein

Experimental group

Description:

20 gram of isolated protein

Treatment:

Dietary Supplement: Whey protein