Proteiomic Fingerprints of Gastric Juice

Kaohsiung Veterans General Hospital

Status: Completed

Conditions: Gastric Cancer

Treatments: Other: normal subject; Other: gastric cancer

Study type: Interventional

Funder types: Other

Identifiers

NCT00834236

VGHKS96-CT2-24

Details and patient eligibility

About

No accurate, inexpensive and non-invasive test for gastric cancer screening is currently available. The investigators' recent study identified a1-antitrypsin and other proteins as potential biomarkers of gastric cancer in gastric juice. The aim of this study was to develop a novel non-invasive modality for detecting gastric cancer by measurement of biomarkers in gastric juice.

Full description

Patients and methods: The study consisted of two parts: (1) investigating the differences in gastric juice biomarker concentrations between gastric cancer patients and controls, and (2) screening gastric cancer using string test to obtain gastric juice followed by immunoassay for biomarker concentration.

Enrollment: 76 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy subjects and gastric cancer patients documented by endoscopy.

Exclusion criteria

• the use of proton pump inhibitors or histamine-2 receptor antagonists within 4 weeks prior to the study
• coexistence of two kinds of gastroduodenal lesions
• coexistence of severe systemic diseases

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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76 participants in 2 patient groups

gastric cancer

Experimental group

Description:

gastric cancer patients

Treatment:

Other: gastric cancer

Other: normal subject

normal subject

Active Comparator group

Description:

healthy subject

Treatment:

Other: gastric cancer

Other: normal subject