Proteomic Analysis of HLA Complex in Solid Cancers: Breast, Ovary, Colon, Rectum, Stomach, and Pancreas

Hillel Yaffe Medical Center

Status: Unknown

Conditions: Breast Neoplasms; Colorectal Neoplasms; Ovarian Cancer; Stomach Neoplasms; Pancreatic Neoplasms

Study type: Observational

Funder types: Other

Identifiers

NCT00419627

ProtHYMC

Details and patient eligibility

About

The purpose of this study is to evaluate the presence of proteins in solid tumors which may lead to an immune response

Full description

The main objective of the study is to evaluate which proteins are presented by the HLA complex of solid tumors. Secondary objectives include to evaluate whether an immune response specific to these proteins has actually been provoked and whether there is a similar immune response following recurrence. Real specimens will be evaluated using PCR and mass spectrometry.

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with adenocarcinoma of breast, colon, rectum, ovary , stomach, pancreas

Exclusion criteria

• Withdrawal of consent
• Small specimen which does not allow to retrieve tissue without interfering with pathologic evaluation