Proteomic Pattern Associated With the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension (PROTEO-CTEPH)

Centre Hospitalier Universitaire de Saint Etienne

Status: Enrolling

Conditions: Chronic Thromboembolic Pulmonary Hypertension

Treatments: Biological: blood sample

Study type: Observational

Funder types: Other

Identifiers

NCT05340023

21CH115

ANSM (Other Identifier)

Details and patient eligibility

About

Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH) is a rare but severe complication of pulmonary embolism (PE). CTEPH is evoked in patients with persistent dyspnea. According to international guidelines, symptomatic patients with perfusion defects on lung scan and Pulmonary Hypertension (PH)-likely transthoracic echo (TTE) must be evaluated in Pulmonary Hypertension (PH)-centers with right heart catheterism, to confirm or rule out the presence of precapillary Pulmonary Hypertension (PH), and precise the group of Pulmonary Hypertension (PH).

Full description

However, persistent dyspnea and perfusion defects are frequent after pulmonary embolism (PE), and the accuracy of transthoracic echo (TTE) is not great for precapillary Pulmonary Hypertension (PH).

This study proposed to seek for a specific proteomic pattern in patients admitted for a suspicion of Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH).

Enrollment: 120 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with a suspicion of Chronic thromboembolic pulmonary hypertension (CTEPH) with a combination of a perfusion lung scan and transthoracic perfusion scan and transthoracic echocardiography compatible with the diagnosis (according to French recommendations)
• Patients who require a right heart catheterization.
• Patient affiliated or entitled to a social security plan
• Patient having received informed information about the study informed about the study

Exclusion criteria

• Patient with a normal perfusion lung scan
• Person under legal guardianship

Trial design

120 participants in 1 patient group

Patient with suspicion of Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH)

Description:

* right cardiac catheterization (usual practice) * a blood sample (inclusion for all patients with suspicion) * if diagnosis of Chronic thromboembolic pulmonary hypertension confirmed a another bood sample at 6 months

Treatment:

Biological: blood sample