Proteomics Analysis for Recognition of Acute Cellular Rejection After Lung Transplantation

Hannover Medical School (MHH)

Status: Unknown

Conditions: Lung Transplantation; Rejection

Study type: Observational

Funder types: Other

Identifiers

NCT00558597

154

Details and patient eligibility

About

In patients with acute rejection after lung transplantation the peptide profile in broncho-alveolar lavage (BAL) and urine should be compared in order to identify a paradigm that allows an non-invasive rejection therapy.

Full description

Goal of the study is the establishment of biomarkers for early diagnosis of acute rejection, followed by a late validation of the paradigm with prospectively collected samples, which will be examined blinded.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with stable graft function
• Patients with acute rejection

Exclusion criteria

• Acute infection
• BOS

Trial design

60 participants in 2 patient groups

1

Description:

30 patients with stable graft function

2

Description:

30 patients with acute rejection after lung transplantation