Proteomics and Genomics Combined With CT to Predict CVD (PREDICT-CVD)

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Status: Active, not recruiting

Conditions: Coronary Artery Disease Progression

Study type: Observational

Funder types: Other

Identifiers

NCT05800093

NL81913.018.22

Details and patient eligibility

About

This study evaluates plaque progression and characteristics in patients with coronary atherosclerosis.

Enrollment: 310 patients

Sex: All

Ages: 50 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients between 50 and 75 years old
• Subjects at intermediate to high risk for ASCVD
• Asymptomatic patients without cardiac chest pain
• Evidence of atherosclerosis on baseline CCTA

Exclusion criteria

• Renal insufficiency, defined as eGFR < 30 ml/min
• History of cardiovascular events (myocardial infarction, peripheral artery disease and ischemic stroke)
• Use of lipid lowering therapy other than statin, ezetimibe or bempedoic acid monotherapy
• Change in lipid lowering therapy in the last 6 months
• Use of more than two antihypertensive agents
• No coronary atherosclerosis at baseline imaging
• Active malignancy requiring treatment
• Atrial fibrillation
• Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator
• Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study.