Protocol for Evaluation of Quarter-Time Cardiac Imaging: 5-Minutes Rest and 3-Minutes Stress Wide Beam Reconstruction (WBR) Versus Full-Time Filtered Back Projection (FBP)

St. Luke's-Roosevelt Hospital Center

Status: Completed

Conditions: Cardiac Diseases

Treatments: Device: quarter-time rest scans reconstructed by WBR (6/8/10 SPS) - Xpress3.Cardiac; Device: quarter-time stress scans reconstructed by WBR (4SPS) - Xpress3.Cardiac

Study type: Observational

Funder types: Other

Identifiers

NCT00661752

quarter-time cardiac SPECT

Details and patient eligibility

About

A new, innovative software image processing method, wide beam reconstruction (WBR), utilizes resolution recovery and incorporates Poisson noise-reduction into the reconstruction process of NM images. This method facilitates the reconstruction of low count density myocardial perfusion SPECT images. Preliminary research indicates that SPECT acquisition time consequently can be reduced by 60% (less than 5 minutes) for rest and by 75% (just over 3 minutes) for stress, while tomographic image quality is maintained, or even improved. Such a decrease in image acquisition time decreases patient discomfort during the tomographic acquisition, decreases the opportunity for patient motion, and improves laboratory efficiency.

Full description

Standard full-time SPECT will be processed using FBP and compared to 3-minute stress and 5-minute rest scans processed with WBR. The following scan parameters will be evaluated: image quality; perfusion defect extent, severity, and reversibility; transient ischemic dilatation; left ventricular end-diastolic volume; left ventricular end-systolic volume; left ventricular ejection fraction; and regional wall motion and wall thickening abnormalities. These parameters will be assessed visually by experienced Nuclear physicians (at least 2 blinded readers) and quantitatively using several different commercially available software programs.

Enrollment: 134 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient is clinically stable
• Patient is able to tolerate additional 8 minutes of scanning
• Patient is willing to undergo additional 8 minutes of scanning

Exclusion criteria

• Unstable patient
• Non-consenting patient

Trial design

134 participants in 4 patient groups

FBP studies

Description:

standard filtered backprojection image processing/reconstruction of full-time acquisition data

Treatment:

Device: quarter-time stress scans reconstructed by WBR (4SPS) - Xpress3.Cardiac

Device: quarter-time rest scans reconstructed by WBR (6/8/10 SPS) - Xpress3.Cardiac

half-time WBR

Description:

wide-beam reconstruction of simulated half-time acquisitions from standard full-time acquisitions

Treatment:

Device: quarter-time stress scans reconstructed by WBR (4SPS) - Xpress3.Cardiac

Device: quarter-time rest scans reconstructed by WBR (6/8/10 SPS) - Xpress3.Cardiac

Quarter-time stress

Description:

4 seconds per stop post-stress SPECT acquisitions reconstructed by the wide-beam reconstruction method

Treatment:

Device: quarter-time stress scans reconstructed by WBR (4SPS) - Xpress3.Cardiac

Quarter-time rest

Description:

6 seconds per stop rest SPECT acquisitions reconstructed by the wide-beam reconstruction method

Treatment:

Device: quarter-time rest scans reconstructed by WBR (6/8/10 SPS) - Xpress3.Cardiac