Protocol to Distinguish Tumor Recurrence From Treatment-Related Necrosis in Patients With High Grade Gliomas

Dartmouth Health

Status: Completed

Conditions: Recurrent High Grade Gliomas

Treatments: Device: 3T MRI

Study type: Observational

Funder types: Other

Identifiers

NCT00942760

DMS-0901

D0901

Details and patient eligibility

About

Brain imaging tests are routinely used to detect the presence of a brain tumor or to evaluate the response to treatment. Sometimes the images obtained are not specific and the only way to establish a diagnosis is by obtaining a tissue sample. The hypotheses of the study is to determine if multimodal MR technique will provide tissue signatures that differentiate between tumor progression and treatment related necrosis in high grade glioma patients.

Enrollment: 12 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically proven high grae glioma with central pathology review at DHMC
• Age 18 equal to or greater than 18 years
• Karnofsky performance greater or equal to 60%
• Patients must have received radiation therapy and chemotherapy but should not have received any anti-angiogenesis therapy.

Exclusion criteria

• Any patient who requires urgent surgical resection of MRI abnormality would not be eligible
• Pregnant women are not eligible

Trial design

12 participants in 1 patient group

Research MRI

Description:

High Grade Glioma patients who show progression based on MRI

Treatment:

Device: 3T MRI