Protocol to Examine Methylation of Tumor Suppression Genes in Women at High Risk of Developing Breast Cancer

Carol Fabian, MD

Status: Completed

Conditions: Breast Cancer

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00323908

9933

Details and patient eligibility

About

A study to examine the correlations between methylation of various genes associated with breast cancer and proliferation and cytomorphology in breast epithelial cells acquired by random periareolar fine needle aspiration of women at high risk for development of breast cancer.

Full description

A study to examine the correlation between gene promotor methylation and benign breast tissue proliferation and cytomorphology collected via random periareolar fine needle aspiration in postmenopausal women at increased risk for breast cancer.

Enrollment: 281 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• women at high risk of developing breast cancer determined by family or personal history
• willing to participate in companion protocol (KUMC HSC#4601) for random periareolar fine needle aspiration (RPFNA) for correlational studies

Exclusion criteria

• exclude women who have been on raloxifene, tamoxifen, letrozole, anastrozole or exemestane within the six months prior to RPFNA

Trial design

281 participants in 1 patient group

1

Description:

Women at high risk for developing breast cancer