Proton and Carbon Ion Radiotherapy for Cervical Cancer

Shanghai Proton and Heavy Ion Center

Status: Completed

Conditions: Cervical Cancer

Treatments: Radiation: proton and carbon ion radiotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05141825

SPHIC-TR-CERC-2021-01

Details and patient eligibility

About

The aim of this study is to evaluate the toxicity and tolerance of proton and carbon ion radiotherapy (PCRT) for cervical cancer.

Full description

To retrospectively analyze cervical cancer patients received radical proton and carbon radiotherapy in our center. The acute and late toxicities, overall survival (OS), local control rate (LC), progression-free survival (PFS) and distant metastasis-free survival (DMFS) were analyzed.

Enrollment: 16 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. . histologically diagnosis of squamous cell carcinoma of the cervix;
2. . International Federation of Gynecology and Obstetrics (FIGO) stage (2014) IB2 - IIIB, without rectum invasion; or FIGO stage IA - IB1, who refused surgery or were contraindication for surgery due to comorbidity diseases;
3. . received proton and carbon ion radiotherapy (PCRT) with or without chemotherapy for curative intention;
4. . Follow-up data available.

Exclusion criteria

1. a previous history of other malignancy;
2. squamous cell carcinoma of the cervix patients who had received surgery;
3. rectum was invaded.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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16 participants in 1 patient group

proton and carbon ion radiotherapy

Experimental group

Description:

proton and carbon ion radiotherapy

Treatment:

Radiation: proton and carbon ion radiotherapy