Proton Pump Inhibitor Use is Associated With High Risk of Pneumonia in Chronic Kidney Disease Patients

Far Eastern Memorial Hospital

Status: Completed

Conditions: Chronic Kidney Disease; Pneumonia

Study type: Observational

Funder types: Other

Identifiers

NCT01588886

101013-E

Details and patient eligibility

About

Chronic kidney disease is a severe medical problem in Taiwan public health issue, which the highest incidence and prevalence rate in the world.Proton pump inhibitors may increase the risk of pneumonia appearance, which were caused by profound irreversible gastric acid suppression. The study purpose was to characterize difference of developing pneumonia in chronic kidney disease of prior use proton pump inhibitors.

Full description

The study used data from Taiwan Health Insurance Research Database; the investigators conducted a population-based cohort study in Taiwan. Case consisted of all patients who had a first diagnosis of chronic kidney disease for the period between 1997 and 2008. The investigators utilized the use of Proton pump inhibitor from chronic kidney disease patients.

Enrollment: 9,000 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic kidney disease

Exclusion criteria

• excluded those patients who had ever been diagnosed with CKD before 1997

Trial design

9,000 participants in 2 patient groups

with PPI

Description:

CKD with PPI use, follow up at least 5 years began PPI use

with or without Pneumonia outcome

Description:

Patients were eligible for inclusion if they received any PPIs treatment between January 1, 1998 and December 31, 2002 and had been diagnosed with pneumonia between January 1, 1998 and December 31, 2008 in an inpatient setting.