Proton Therapy for Hodgkin Lymphoma (HL01)

University of Florida

Status: Completed

Conditions: Hodgkin Lymphoma

Treatments: Radiation: Intensity Modulated Radiation Plan; Radiation: Proton Radiation Plan; Radiation: Conventional Photon Radiation Plan

Study type: Interventional

Funder types: Other

Identifiers

NCT00850200

UFPTI 0806 - HL01

Details and patient eligibility

About

The purpose of this study is to reduce the risk of radiation related side effects and complications by treating with radiation (protons or photons) that exposes less of normal organs to low dose radiation.

Full description

3 treatment plans will be created to deliver between a total of 21-39.6 Gray (Gy)/Centigray Equivalents (CGE) to the planning target volume (PTV).

1. Proton Plan
2. Conventional Plan
3. Intensity Modulated Radiotherapy (IMRT) Plan

The patient will then receive the radiation modality with the lowest percentage of the body receiving 4 Gy (V4Gy/CGE)

Enrollment: 20 patients

Sex: All

Ages: 6+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed "classic" Hodgkin lymphoma.
• Completed chemotherapy.

Exclusion criteria

• Prior radiotherapy.
• Prior or concurrent cancer other than non-melanomatous skin cancer.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 3 patient groups

Proton Radiation Plan

Experimental group

Treatment:

Radiation: Proton Radiation Plan

Conventional Photon Radiation Plan

Active Comparator group

Treatment:

Radiation: Conventional Photon Radiation Plan

Intensity Modulated Radiation Plan

Active Comparator group

Treatment:

Radiation: Intensity Modulated Radiation Plan