Proving Utility of a New Field-cycling MRI Prototype in Acute Stroke Patients (PUFFINS 3)

University of Aberdeen

Status

Not yet enrolling

Conditions

Stroke Acute

Treatments

Other: 3T MRI research scan

Other: Follow up 3T MRI research scan

Other: Blood samples for clotting experiments in vitro

Other: Follow up Field-Cycling Imaging research scan

Other: Field-Cycling Imaging research scan

Study type

Observational

Funder types

Other

Identifiers

NCT07004140

2-001-25

25/SS/0021 (Other Identifier)

Details and patient eligibility

About

The goal of this study is to test if a new type of MRI scanner, called Field-Cycling Imaging (FCI), can show changes in the brain within the first day of a stroke due to a blocked blood vessel or bleeding in the brain. The main question it aims to answer is:

• Can FCI identify brain tissue that might recover within the first few hours after a stroke begins?

Participants will undergo a standard MRI scan and an FCI scan, as soon as possible after hospital admission.

Participants who have had a blocked blood vessel will also provide a blood sample and will have a follow up visit at 30 days for repeat of both scans and providing another blood sample.

Enrollment

40 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Acute stroke (<24 hours from symptom onset).
NIHSS ≥4 and <25 with cortical involvement and/or large vessel occlusion on baseline imaging.
Able to undergo 3T and FCI MRI <24h of onset.
With or without thrombolysis.

Exclusion criteria

Contraindications to MRI.
Medically unstable.
Unable to comprehend or comply with instructions regarding scanning
Prior mRS of >3.
Identified for thrombectomy.
Non-stroke pathology or previous cortical infarct on CT scan > 1/3 of middle cerebral artery territory.