Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer

Nanchong Central Hospital

Status: Enrolling

Conditions: Gastric Cancer; Gastroesophageal Reflux Disease; Proximal Gastric Adenocarcinoma

Treatments: Procedure: Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty

Study type: Interventional

Funder types: Other

Identifiers

NCT05514769

20220720

Details and patient eligibility

About

This research is designed to compare proximal gastrectomy anterior anastomosis with pyloroplasty with esophagogastric anastomosis for gastric cancer. Gastroesophageal reflux disease, postoperative quality of life, short term outcomes, and long term outcomes will be compared.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Histologically confirmed adenocarcinoma of the stomach, T1-T4 stages.
2. Eastern Cooperative Oncology Group performance status of 0 or 1.
3. Adequate organ function.

Exclusion criteria

1. Patients had distant metastasis.
2. oesophageal invasion of more than 3 cm.
3. Borrmann type 4 or large (more than 8 cm) type 3 carcinoma.
4. Previous chemotherapy or radiation therapy for any other malignancies.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty (GAP)

Experimental group

Description:

The reconstruction including esophagogastric anastomosis and pyloroplasty for patients who underwent proximal gastrectomy . The anastomosis locate in the anterior of gastric stump.

Treatment:

Procedure: Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty

Control

Active Comparator group

Description:

The reconstruction including esophagogastric anastomosis and pyloroplasty for patients who underwent proximal gastrectomy . The anastomosis locate in the posterior or side of gastric stump.

Treatment:

Procedure: Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty