PRP Gel in Wound Closure in Recurrent CS (PRP-CS)

Ain Shams University

Status and phase: Completed; Phase 2; Phase 1

Conditions: Scar; Previous Cesarean Section; Previous Incision

Treatments: Biological: saline; Biological: platelet rich plasma gel

Study type: Interventional

Funder types: Other

Identifiers

NCT02775747

PRP-CS

Details and patient eligibility

About

There is limited application of the use of PRP in obstetrics, therefore there is a need for assessment if it is efficacy in improving skin wound healing in cesarean section.

Full description

This study aims to assess the efficacy of injection of platelet rich plasma into the wound of recurrent cesarean section for improving wound healing and enhancing the shape of the wound in women undergoing cesarean section.

Enrollment: 128 patients

Sex: Female

Ages: 25 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• elective cesarean section
• Body mass index 18:25
• Hemoglobin more than 10.5 g/d
• Albumin within normal more than or equal 3.5 g/d

Exclusion criteria

• medical disorders(Diabetes mellitus,heart disease,hypertension,systemic lupus erythematosus)
• high risk pregnancy as (placenta previa,placenta accreta)
• patient on corticosteroids medication
• primigravida subjected cesarean section
• complicated cesarean section (increased operation time,blood transfusion, drain, scrubbing of multiple surgeons)
• cesarean section due to chorioaminionitis
• postoperative complication such as:postpartum hemorrhage, paralytic ileus, sever distention..) will be dropped out from the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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128 participants in 2 patient groups, including a placebo group

platelet rich plasma gel

Experimental group

Description:

Injection of Platelet rich plasma (PRP) gel in 64 cases at time of wound closure in women undergoing cesarean section for improving wound healing after fullfit to all the inclusion and exclusion craiteria

Treatment:

Biological: platelet rich plasma gel

Saline

Placebo Comparator group

Description:

64 Controlled Women with recurrent cesarean section and fullfit to all the inclusion and exclusion craiteria will reseve saline injection at time of wound closure

Treatment:

Biological: saline