PRP Intrauterine Infusion in Thawed Embryo Cycles

Tanta University

Status and phase: Completed; Phase 4

Conditions: Evaluations

Treatments: Biological: Normal saline; Biological: Platelet rich plasma intrauterine infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT03734042

PRPF

Details and patient eligibility

About

All patients prepared to thawed embryo transfer were classified into 2 groups one group will receive platelet rich plasma (PRP) infusion intrauterine and the other group will not receive platelet rich plasma (PRP) infusion

Full description

Patients candidates for Thawed embryo transfer with Repeated implantation failure were recruited from 3 centers and classified into 2 groups:

Group I: Will receive platelet rich plasma (PRP) intrauterine infusion at day 11

Group II: Not receiving platelet rich plasma (PRP)

Enrollment: 102 patients

Sex: Female

Ages: 20 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients age 20-35 years
• Patients with previous implantation failure
• Patients with thin endometrium<7 mm

Exclusion criteria

• Patients older than 40 years
• Patients with fresh embryo transfer
• Patients with abnormal uterine cavity septate, or bicornuate uterus
• Patients with abnormal male factor or tubal factor
• Patients with abnormal embryos grade B or C.
• Patients with immunological disorders as thyroidits or systemic lupus or rheumatoid arthritis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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102 participants in 2 patient groups, including a placebo group

PRP group

Experimental group

Description:

These patients will receive platelet rich plasma intrauterine infusion at day 11

Treatment:

Biological: Platelet rich plasma intrauterine infusion

Control group

Placebo Comparator group

Description:

These patients will receive intrauterine normal saline infusion at day 11

Treatment:

Biological: Normal saline