PRV-based Detection of CAD in Comparison to Standard Methods (PRV-KORO)

University Medicine Greifswald

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Other: Diagnostic algorithm

Study type: Observational

Funder types: Other

Identifiers

NCT02404948

PRV-Koro-Study-001

Details and patient eligibility

About

This is a validation study comparing a pulse wave based algorithm for the detection of coronary artery disease with parameters from coronary angiography, echocardiography and cardiogoniometry.

Full description

The study will validate a pulse wave based algorithm for the detection of coronary artery disease (CAD) with parameters from standard methods. Subjects will be patients admitted to coronary angiography due to suspected CAD. Pulse wave signals will be analyzed according to novelly established algorithm regarding the presence of CAD and/or myocardial ischemia. These results be compared to the diagnoses made by coronary angiography (primary endpoint): presence of minimum one coronary artery stenose >=50%. For secondary analyses, results will be compared to parameters form echocardiography and cardiogoniometry.

Enrollment: 156 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Coronary angiography indication present
• informed written consent

Exclusion criteria

• Previous coronary angiography
• Known CAD (history of coronary angioplasty, stent implantation and/or bypass surgery)
• atrial fibrillation (at time of measurement)
• severe ventricular extrasystole (e.g. >=10% ventricular extrasystoles, bigemina)
• pregnancy, lactation