Pseudoexfoliation and Chronic Kidney Disease

Corum State Hospital

Status: Completed

Conditions: Chronic Kidney Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01693744

LNiyaz

Details and patient eligibility

About

Background: Pseudoexfoliation (PEX) is characterised by the deposition of fibrillar material in an eye structures and many other parts of the body including kidneys and blood vessels. As both PEX and chronic kidney disease (CKD) are associated with oxidative stress and endothelial dysfunction we studied if the risk of PEX was increased in patients with CKD.

Methods: Patients over age 40 with the diagnosis of CKD were included in the study. Chronic kidney disease was diagnosed as decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m². Study groups were arranged as group 1 consisting of HD receiving patients, group 2 consisting of stage 1-4 CKD patients and group 3 consisting of patients with normal kidney functions (control group). Demographic properties and the rate of PEX were evaluated and compaired between the groups.

Enrollment: 358 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All patients with chronic kidney disease stage 1-5

Exclusion criteria

• History of eye trauma or surgery

Trial design

358 participants in 3 patient groups

Dialysis patients

Description:

Patients with stage 5 chronic kidney disease undergoing haemodialysis

Chronic kidney disease patients

Description:

Stage 1-4 Chronic kidney disease patients

Control group

Description:

Patients with normal renal functions