Psilocybin for Prolonged Grief Disorder

University of Virginia

Status and phase

Enrolling

Early Phase 1

Conditions

Prolonged Grief Disorder

Treatments

Diagnostic Test: Functional Magnetic Resonance Imaging (fMRI)

Drug: Psilocybin 25 mg

Study type

Interventional

Funder types

Other

Identifiers

NCT06724289

HSR231647

Details and patient eligibility

About

The primary purpose of this study is to explore the feasibility of conducting a clinical trial on the effects of psilocybin for individuals with prolonged grief disorder (PGD).

Full description

The study aims to investigate whether a single dose of 25 mg psilocybin can reduce the symptoms of grief and trauma associated with Prolonged Grief Disorder (PGD). It is hypothesized that psilocybin will significantly reduce the symptoms of PGD, and that the treatment will facilitate subjective mystical, spiritual, or insightful experiences, which in turn may contribute to the alleviation of grief and trauma symptoms. Neuroimaging will be used to help researchers better understand the relationship between grief and brain functions, comparing pre- and post-dose scans. Participants will undergo two MRI (magnetic resonance imaging) where they are asked to look at images (this is called a functional MRI or fMRI).

Enrollment

12 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Ages 18 years old up to and including 65 years of age
Negative UDS results for illicit drugs at screening and prior to each drug administration session
Consent to all study procedures
Have an existing diagnosis of Prolonged Grief Disorder. May also be determined to have Complicated Grief Disorder without official diagnosis as determined by PI or designate based on DSM V criteria
Score of greater than 25 on the Inventory of Complicated Grief
Agree to abstain from any psychoactive drugs on the day prior to and the day of the drug administration session
People of childbearing potential that are sexually active must agree to continue or initiate practice of a highly effective means of birth control, alone or in combination with another, throughout the study. Highly effective options are: implants, intrauterine devices (IUD), and sterilization. Exclusive use of condoms is not effective.
Be judged by study team clinicians to be at low risk for suicidality as determined by MINI, Columbia Suicide Severity Scale, and the Patient Health Questionnaire-9.
Concurrent psychotherapy or pharmacotherapy with SSRIs, SNRIs, and/or bupropion (< 300 mg bupropion) is allowed if the type and frequency of the therapy has been stable for at least two months prior to screening and is expected to remain stable during participation in the study
Be otherwise medically stable as determined by screening for medical problems via a personal interview, a medical questionnaire, a physical examination, an electrocardiogram (ECG), urine beta-HCG, and urine toxicology screen
Participant must agree to consume approximately the same amount of caffeine-containing beverage (e.g., coffee, tea) that they consume on a usual morning, before arriving at the research unit on the mornings of drug session days. If the participant does not routinely consume caffeinated beverages, they must agree not to do so on session days
Agree not to take any PRN medications on the mornings of drug sessions
Agree not to take sildenafil (Viagra®), tadalafil, or similar medications within 72 hours of each drug administration
Agree that for one week before each drug session, participant will refrain from taking any nonprescription medication, nutritional supplement, or herbal supplement except when approved by the study investigators. Exceptions will be evaluated by the study investigators and will include acetaminophen, non-steroidal anti-inflammatory drugs, and common doses of vitamins and minerals
Willingness and ability to remain within the observation room for the duration of the study visits up to 10 hours
Willingness and ability to follow study protocol as directed by research staff
Willing and able to attend all sessions in the study and complete follow up assessments
Fluent in English
Ability to provide one photo of a deceased loved one and one photo of a living loved one, as required for the grief elicitation task.

Exclusion criteria

General medical exclusion criteria:

Previous use of a psychedelic drug may be exclusionary depending on frequency, context, and participant safety as determined by the PI or designate.
Person who is pregnant, nursing, or planning to get pregnant determined at screening and before drug session by urine test or self-report
People of childbearing potential that are sexually active who are not practicing an effective means of birth control
Cardiovascular conditions: coronary artery disease, stroke, angina, a clinically significant ECG abnormality (e.g., atrial fibrillation), prolonged QTc interval (i.e., QTc > 450 msec), heart valve, or TIA in the past year.
History of head trauma with neurological deficit; seizures, or neurologic disorders including cerebrovascular disease, epilepsy, or neurogenerative diseases
Type 1 diabetes
BMI <18
Currently taking on a regular (e.g., daily) basis any antidepressant medications other than SSRIs, SNRIs, or bupropion, or any other medications that have a primary centrally-acting serotonergic effect, including MAOIs. Bupropion dosage must be < 300 mg in order to be included
Nicotine dependence that would be incompatible with remaining in study area for the entirety of the visit
Prescribed or illicit use of benzodiazepines or opioids within 4 weeks prior to screening
Baseline blood pressure greater than 139/79 (after repeat measures) unless stable with medication as determined by PI or PI designate
Taking any muscle relaxers, antihistamines, or other medications known to cause lethargy or impair cognitive ability within one day prior to psilocybin session
Serious medical comorbidity requiring medical intervention or close supervision
History of claustrophobia
Any court mandated or legal restrictions that would impair the participant from attending all visits
Inability to follow and comply with all study procedures
Deemed unable to meaningfully or safely participate in the study
Any legal judgement toward subject determined to interfere with study attendance or jeopardize compliance with study protocol determined by PI or designate
Individuals who are unable to undergo MRI as determined by MRI pre-screening.

General psychiatric exclusion criteria:

Score of less than 25 on the Inventory of Complicated Grief
Severe psychiatric disorder (other than depression) within 6 months or lifetime history of serious psychiatric or neurological disorders, including bipolar disorder, or active psychosis
Clinically significant suicidal ideation (e.g., with strong intent or means) within past 6 months or lifetime history of suicide attempt based on the MINI, Patient Health Questionnaire-9 or Columbia-Suicide Severity Scale. At any point during the study, a participant may be withdrawn from the study for concerns of suicidality and provided follow-up care by our team or a referral to care if needed.
Current or past history of meeting DSM-5 criteria for schizophrenia spectrum or other psychotic disorders, or bipolar I disorder
Current or previous history within one year of meeting DSM-5 criteria for a moderate or severe alcohol, or other drug use disorder (excluding tobacco, caffeine, and cannabis)
Nicotine dependence that would be incompatible with an individual to be nicotine free for 8-10 hours on a psilocybin session day
Have a first degree relative with schizophrenia or other psychotic disorders (except substance/medication-induced or due to another medical condition), or bipolar I disorder