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PSMA-PET Imaging in Patients With Metastatic Prostate Cancer: Institutional Evaluation of Detection Yield Performance and Reproducibility

C

Centre hospitalier de l'Université de Montréal (CHUM)

Status

Completed

Conditions

Prostate Cancer

Treatments

Diagnostic Test: PSMA -PET/CT scanning

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

A promising imaging technique involving new prostate specific membrane antigen (PSMA) positron emission tomography (PET) tracers is emerging in metastatic prostate cancer (PCa). This approach has demonstrated higher sensitivity in detecting metastases, prior to and during therapy, than current imaging standard of care (CT and bone scan).

PSMA is expressed in the vast majority of PCa tissue specimens and its degree of expression correlates with a number of important metrics of PCa tumor aggressiveness.

[18F]DCFPyL is a promising high-sensitivity second generation PSMA-targeted urea-based PET probe. Studies employing second-generation PSMA PET/CT imaging in men with biochemical progression after definitive therapy suggest detection of metastases in over 60% of men imaged. In fact, PSMA-based PET has so far proven to have higher sensitivity than any other modality for localization of the site of recurrence. Applications that show promise and require further investigation include the characterization and risk stratification of primary PCa, complete staging of metastatic PCa to allow for PSMA-targeted radiotherapy and improved identification of patients with oligometastatic disease.

The objective of this study is to explore the detection yield of PSMA-PET in a pilot cohort of patients at CHUM and establish the repeatability of the technique before investigating it more widely.

Enrollment

29 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Ability to provide informed consent
  • Metastatic prostate cancer.
  • At least 18 years of age
  • Standard imaging (bone scan, CT abdo/pelvis/chest) within 6 weeks of consent.

Exclusion criteria

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

29 participants in 1 patient group

PSMA -PET/CT scanning
Experimental group
Treatment:
Diagnostic Test: PSMA -PET/CT scanning

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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