Psorcast Mobile Study

Sage Bionetworks

Status: Enrolling

Conditions: Psoriatic Nail; Psoriasis; Psoriatic Conditions; Joint Pain; Rheumatologic Disease; Plaque Psoriasis; Dermatologic Disease; Psoriatic Arthritis; Dactylitis

Treatments: Behavioral: 30 Second Walk; Behavioral: Digital Jar Open; Behavioral: Finger and Toe Photos; Behavioral: Psoriasis Draw; Behavioral: Psoriasis Area Photo; Behavioral: Participant self-assessment surveys; Other: Psorcast mobile application

Study type: Observational

Funder types: Other

Identifiers

NCT05621369

202110921

Details and patient eligibility

About

The purpose of this study is to understand variation in the symptoms of psoriasis and psoriatic arthritis using simple, scalable smartphone-based measurements. This study uses an iPhone app to record these symptoms through questionnaires and sensors.

Full description

Psoriatic disease exhibits a spectrum of symptoms and can transition from psoriasis (PsO), largely affecting the skin, to psoriatic arthritis (PsA) involving widespread musculoskeletal inflammation. Early detection of the PsO-to-PsA transition and rapid administration of effective treatment is essential, as a delay in diagnosing PsA by as little as 6 months can lead to irreversible joint damage. This "ticking clock" paradigm drives the need for frequent monitoring and effective therapeutic intervention as early as possible to attenuate or possibly prevent disease progression. Using a suite of smartphone-based measurements in an app called Psorcast (psoriasis forecasts), we aim to aggregate weekly, symptom measurements from participants in a remote, longitudinal observational study to map the trajectories of treatment response and disease progression. In this study, we will explore measurements of psoriatic disease activity at least an order of magnitude more frequently (weekly vs. quarterly) than standard clinical practice or clinical trial designs. This study is not meant to provide a medical diagnosis, treatment, or medical advice. It is meant to provide a scalable, inexpensive, non-invasive and frequent measure and tracking of psoriasis and psoriatic arthritis for research purposes.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult age 18 and older who consent to participate in the study
• Own a compatible iPhone or iPod Touch device running iOS 12.2 or above
• Be able to read and understand an official language of the country of participation

Exclusion criteria

• Age 17 years or younger
• Not a resident of the a country where the app is approved for use
• Not have a personal (i.e., not shared) iPhone (4s or newer running iOS 8.0 or later)
• Not be able to read and understand an official language of the country of participation

Trial design

1,000 participants in 3 patient groups

Participants with Psoriasis

Description:

People who report a diagnosis of Psoriasis. Participants are invited via the Psorcast mobile application to complete the following assessments: Participant self-assessment surveys, skin assessments (Psoriasis Area Draw and Psoriasis Area Photo) and musculoskeletal assessments (Finger/Toe Photos, Joint Count, Digital Jar Open, 30s Walk).

Treatment:

Other: Psorcast mobile application

Behavioral: Psoriasis Area Photo

Behavioral: Psoriasis Draw

Behavioral: Participant self-assessment surveys

Behavioral: 30 Second Walk

Behavioral: Digital Jar Open

Behavioral: Finger and Toe Photos

Participants with Psoriatic Arthritis

Description:

People who report a diagnosis of Psoriatic Arthritis. Participants are invited via the Psorcast mobile application to complete the following assessments: Participant self-assessment surveys, skin assessments (Psoriasis Area Draw and Psoriasis Area Photo) and musculoskeletal assessments (Finger/Toe Photos, Joint Count, Digital Jar Open, 30s Walk).

Treatment:

Other: Psorcast mobile application

Behavioral: Psoriasis Area Photo

Behavioral: Psoriasis Draw

Behavioral: Participant self-assessment surveys

Behavioral: 30 Second Walk

Behavioral: Digital Jar Open

Behavioral: Finger and Toe Photos

Participants without Psoriasis or Psoriatic Arthritis

Description:

People who report no prior diagnosis of Psoriasis or Psoriatic Arthritis. Participants are invited via the Psorcast mobile application to complete the following assessments: Participant self-assessment surveys, skin assessments (Psoriasis Area Draw and Psoriasis Area Photo) and musculoskeletal assessments (Finger/Toe Photos, Joint Count, Digital Jar Open, 30s Walk).

Treatment:

Other: Psorcast mobile application

Behavioral: Psoriasis Area Photo

Behavioral: Psoriasis Draw

Behavioral: Participant self-assessment surveys

Behavioral: 30 Second Walk

Behavioral: Digital Jar Open

Behavioral: Finger and Toe Photos