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Psoriatic Immune Response to Tildrakizumab

University of California San Francisco (UCSF) logo

University of California San Francisco (UCSF)

Status and phase

Enrolling
Phase 4

Conditions

Psoriasis Vulgaris

Treatments

Drug: Tildrakizumab Prefilled Syringe

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT05390515
22-36503

Details and patient eligibility

About

This study aims to assess cutaneous and blood immune cell function of patients with psoriasis before and after initiation of treatment with the IL23 blocker, tildrakizumab.

Full description

This is a one-arm, open-label study to examine the effect of Tildrakizumab on cutaneous and blood immune cells of psoriatic patients. Ten subjects with moderate to severe psoriasis will be enrolled. Biopsy and blood samples will be collected before and during treatment and undergo molecular profiling to assess for tildrakizumab-corrected signatures.

Enrollment

10 estimated patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • 18 years of age or older
  • Patients with moderate-severe psoriasis or > 5% body surface area affected.

Exclusion criteria

  • taking systemic immunosuppressives in the last 4 weeks
  • pregnancy
  • severe immunodeficiency (either from genetic or infectious causes).
  • tuberculosis or other active serious infection
  • active systemic malignancy.
  • breast-feeding
  • Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

10 participants in 1 patient group

Tildrakizumab treatment
Experimental group
Description:
Biological/vaccine: tildrakizumab
Treatment:
Drug: Tildrakizumab Prefilled Syringe

Trial contacts and locations

1

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Central trial contact

Raymond Cho, MD, PhD

Data sourced from clinicaltrials.gov

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