Psychological Health and Adverse Childhood Experiences in Myasthenia Gravis: Online Mental Health BMI Learning Program

Jiann-Horng Yeh

Status: Completed

Conditions: Depressive Symptoms; Myasthenia Gravis; Psychological Stress; Quality of Life (QOL); Emotional Regulation; Mental Well-being; Activities of Daily Living; Adverse Childhood Experience; Well-Being, Psychological; Mental Health; Psychological Well-being

Treatments: Behavioral: Positive Mental Health BMI Learning Program

Study type: Interventional

Funder types: Other

Identifiers

NCT07291713

20230731R

Details and patient eligibility

About

This study evaluated psychological health in patients with myasthenia gravis (MG) using an online behavioral program called the "Positive Mental Health BMI Learning Program." The program consisted of four short video units focused on interpersonal support, emotional regulation, and personal meaning. Patients receiving care in the neurology outpatient clinic were invited to complete questionnaires before and after viewing the online program. Psychological well-being, depressive symptoms, daily functioning, and quality of life were assessed to describe participants' mental health status and changes observed over the course of the program.

Full description

Participants completed sociodemographic questionnaires, adverse childhood experiences (ACEs) assessments, and four psychological and disease-related measures: the Myasthenia Gravis Activities of Daily Living Scale (MG-ADL), the Myasthenia Gravis Quality of Life 15-item scale (MG-QOL15), the mental health BMI indicator (mBMI), and the Patient Health Questionnaire-9 (PHQ-9). The study collected baseline data prior to the online program and post-intervention data after completion of the four video units. Analyses examined associations between ACE exposure and psychological measures, as well as changes in clinical and psychological indicators across the intervention period.

Enrollment: 77 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with a confirmed diagnosis of myasthenia gravis (MG) based on acetylcholine receptor antibody testing, single-fiber electromyography, repetitive nerve stimulation, or chest computed tomography.
• Individuals able to clearly express their own intentions.
• Individuals without cognitive impairment or psychiatric disorders.
• Individuals who are able to use Facebook and who agree to participate in the study and provide written informed consent.

Exclusion criteria

• Individuals who do not have a diagnosis of MG.
• Patients who are unable to communicate adequately in Mandarin, Taiwanese, English, or written form.
• Individuals with head trauma, psychiatric symptoms, or cognitive impairment that may interfere with verbal expression.

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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77 participants in 1 patient group

Intervention Group

Experimental group

Description:

All participants were assigned to a single intervention arm and received the Positive Mental Health BMI Learning Program. This program consisted of four pre-recorded online video units delivered over four months through a closed Facebook group. The units covered interpersonal support, emotional regulation, and self-worth and meaning. Participants completed pre-test assessments before beginning the program and post-test assessments after completing all four units.

Treatment:

Behavioral: Positive Mental Health BMI Learning Program