Psychological Intervention and Physiotherapy With Medication Improves CRPS Patients Outcome (MultiModCRPS)

Helsinki University Central Hospital (HUCH)

Status and phase: Completed; Phase 4

Conditions: CRPS

Treatments: Other: Physiotherapy intervention; Behavioral: Psychological intervention; Drug: Morphine, memantine

Study type: Interventional

Funder types: Other

Identifiers

NCT02467556

Helsinki University Hospital

Details and patient eligibility

About

A ten week open label study intervention to evaluate the outcome for a psychological intervention combined with physiotherapy and medication with memantine-morphine in 10 CRPS patients.

Full description

Ten CRPS I patients attended an intervention for 10 weeks. First, the medication was started with morphine 10mg adding gradually to 30 mg per day. Then, in addition to morphine, memantine 5 mg was started adding the dose gradually up to 40 mg per day if tolerated. Physiotherapy and psychological intervention were mostly carried out in a weekly group gathering with home exercises that were recorded to a diary. Psychological and physiotherapy interventions lasted for eight weeks. A neurological examination was done before and after the intervention as well as a separate physiotherapist examination of the hands. Patients filled out questionnaires of mood, quality of life, pain, and CRPS descriptions before and after the intervention.

Enrollment: 10 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CRPS type 1 for at least 6 months,
• pain NRS 4 or more

Exclusion criteria

• major psychiatric or neurological disease

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

intervention

Other group

Description:

Open label study with psychological intervention and physiotherapy intervention with medication of morphine, memantine for ten weeks (morphine 30mg tbl per day and memantine up to 40mg tbl per day if tolerated).

Treatment:

Other: Physiotherapy intervention

Behavioral: Psychological intervention

Drug: Morphine, memantine