Psychosocial Group Interventions for Depression (PsySysNe)

University of Eastern Finland

Status: Completed

Conditions: Depression

Treatments: Other: Treatment as usual; Behavioral: Befriending; Behavioral: CBASP

Study type: Interventional

Funder types: Other

Identifiers

NCT02149381

PsySysNe

Details and patient eligibility

About

A total of 384 patients suffering from chronic depressive disorder will be randomized to receive treatment as usual, CBASP, or befriending for a period of five months. The primary outcome is change in Montgomery-Åsberg Depression Scale. Secondary outcomes include changes in self-reported psychiatric symptoms, biomarkers determined from venous blood samples, and neurophysiological parameters. The data gathering is performed at pre- and post intervention stages (i.e., at baseline and at five months). A follow-up questionnaire is sent to the participants six months after the intervention.

Full description

The efficacy of 20-week group-CBASP as compared to TAU is evaluated by RCT in a psychiatric outpatient clinics. The recruition is completed.

Enrollment: 82 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-65
• Moderate or severe major depression with duration of a minimum of two years OR "double depression" (dysthymia and moderate/severe major depression simultaneously) OR moderate or severe major depression with duration of a minimum of two years, only partially remitted during the time period

Exclusion criteria

• Psychotic disorder
• Bipolar disorder
• Current substance abuse (excluding nicotine)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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82 participants in 3 patient groups

CBASP

Experimental group

Description:

Cognitive Behavioral System of Psychotherapy is a manual-based group intervention for chr depression (20 weeks).

Treatment:

Other: Treatment as usual

Behavioral: CBASP

Befriending

Active Comparator group

Description:

Befriending is a social support intervention

Treatment:

Other: Treatment as usual

Behavioral: CBASP

Treatment as usual

Active Comparator group

Description:

Conventional psychiatric outpatient treatment (individual counseling)

Treatment:

Behavioral: Befriending

Behavioral: CBASP