PTEN-AKT-FOXO3 Gene Expression Relation With Low-ovarian Reserve in Endometriomas

Bursa Uludag University

Status: Unknown

Conditions: Ovarian Reserve, Endometrioma, PTEN-AKT-FOXO3 Gene Expression

Treatments: Genetic: PTEN-AKT-FOXO3 Gene Expression

Study type: Observational

Funder types: Other

Identifiers

NCT04058912

UU-MREC-2019-5/28

Details and patient eligibility

About

In this study, we aimed to investigate the relationship between PTEN-AKT-FOXO3 gene expression and decrease in ovarian reserve in the presence of endometrioma and other benign ovarian pathologies.

Full description

It is known that the presence of endometrioma negatively affects ovarian reserve. The development of endometriosis and the effect of the presence of endometrioma on ovarian reserve due to decreased PTEN expression are considered. This study was designed to compare ovarian PTEN-AKT-FOXO3 gene expression and ovarian reserve in patients with underwent surgery caused by endometrioma and those who had ovarian pathology due to other benign causes and PTEN-AKT-FOXO3 gene expression level will be evaluated by RT-PCR analysis.

Enrollment: 60 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. To be in the range of 18-40 years 2) Patients with an operation indication with >=5 cm endometrioma 3) Patients with operation plan due to non-endometrioma ovarian pathologies

Exclusion criteria

• 1)Patients over the age of 40 2)Patients with suspected malignancy 3)Follow-up patients without indications for operation

Trial design

60 participants in 2 patient groups

PATİENCE GROUP

Description:

1. To be in the range of 18-40 years 2. Patients with an operation indication with \>=5 cm endometrioma 1. Symptomatic patients due to endometrioma (dysmenorrhea, dyspareunia, chronic pelvic pain, etc.) 2. Patients who will be followed for IVF cycle due to infertility

Treatment:

Genetic: PTEN-AKT-FOXO3 Gene Expression

PATİENCE-CONTROL GROUP

Description:

1. To be in the range of 18-40 years 2. Patients with operation plan due to non-endometrioma ovarian pathologies 1. Symptomatic patients with benign ovarian pathology (such as chronic pelvic pain, compression, syphilomas, dysmenorrhea, dyspareunia, etc.) 2. Asymptomatic, despite a 6-month follow-up period, increase in cyst size or become symptomatic

Treatment:

Genetic: PTEN-AKT-FOXO3 Gene Expression