Puerarin Effects on Alcohol Drinking (PAD)

Mass General Brigham

Status and phase: Completed; Phase 2

Conditions: Alcohol Abuse

Treatments: Drug: Puerarin, Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT00854724

P-000726

R44AA152200 (Other Grant/Funding Number)

Details and patient eligibility

About

This research is designed to assess the impact of pretreatment with puerarin (NPI-031G), a major ingredient in the plant kudzu, on alcohol drinking. Hypothesis: Short-term treatment with this compound will reduce alcohol self-administration in a simulated natural settings laboratory.

Full description

Participants will have an opportunity to drink up to 6 beers, plus water and juice, during a 90 minute afternoon drinking session in our simulated apartment room laboratory. Drinking sessions will be conducted in the afternoon after participants take puerarin or placebo for 7 days.

Enrollment: 16 patients

Sex: All

Ages: 21 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• moderate to heavy alcohol drinkers (20+ drinks per week)

Exclusion criteria

• alcohol dependence or treatment-seeking drinkers
• other drug abuse or dependence
• psychiatric disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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16 participants in 2 patient groups, including a placebo group

Puerarin

Active Comparator group

Treatment:

Drug: Puerarin, Placebo

Placebo

Placebo Comparator group

Description:

Sugar beet filler in capsule

Treatment:

Drug: Puerarin, Placebo