Pulmonary Assessment in Thoracic Insufficiency Syndrome Patients

Children's Hospital of Philadelphia (CHOP)

Status: Enrolling

Conditions: Thoracic Insufficiency Syndrome

Treatments: Device: Xenon-129

Study type: Interventional

Funder types: Other

Identifiers

NCT04977830

20-017344

Details and patient eligibility

About

Thoracic insufficiency syndrome (TIS) is a complex condition that involves chest wall deformities that can affect normal breathing and lung growth. In most cases, children with TIS are also born with spine disorders such as scoliosis. The inability of the thorax to support normal respiration or lung growth can cause respiratory distress and even mortality. Investigators aim to validate MRI imaging sequences to use as an assessment tool for pulmonary function.

Enrollment: 5 estimated patients

Sex: All

Ages: 6 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Males or females 6 to 18 years old diagnosed with thoracic insufficiency syndrome who are undergoing surgery

Exclusion criteria

• patients not diagnosed with thoracic insufficiency syndrome

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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5 participants in 1 patient group

Thoracic Insufficiency Group

Other group

Description:

Thoracic insufficiency syndrome patients undergoing surgery

Treatment:

Device: Xenon-129