Pulmonary Diffusing Capacity During Acute Exercise in Patients With COPD (DiffLung2)

Rigshospitalet

Status: Enrolling

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Diagnostic Test: Acute exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT05583396

DiffLung2

Details and patient eligibility

About

The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) during exercise may be a useful physiological measure of alveolar-capillary reserve in patients with Chronic obstructive pulmonary disease (COPD). The present study investigated the test-retest reliability of DLCO/NO-based metrics.

Full description

The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) has recently been standardised and validated for clinical use. It is thus ideal for assessing acute changes in pulmonary diffusing capacity and its components during various physiological manoeuvres. These changes are thought to involve acute changes in pulmonary perfusion and are notably relevant for patients with chronic obstructive pulmonary disease (COPD), in which they may be related to exertional dyspnoea. The aim of the present study is to investigate the effects of acute exercise on pulmonary diffusing capacity, and to determine the day-to-day repeatability of such assessments.

Enrollment: 15 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic obstructive pulmonary disease (GOLD II + III)

Exclusion criteria

• Known heart disease
• Pregnancy
• Disease within two weeks prior to inclusion

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

Acute exercise

Other group

Description:

Pulmonary diffusing capacity using the DLCO/NO technique is assessed at rest and during exercise (60% of maximal workload on a bicycle ergometer)

Treatment:

Diagnostic Test: Acute exercise