Pulmonary Effects of 100% Biodiesel Exhaust (BD100Broncho)

U

Umeå University

Status

Completed

Conditions

Inflammation

Treatments

Other: Bronchoscopy

Study type

Interventional

Funder types

Other

Identifiers

NCT02690571
184-31M

Details and patient eligibility

About

Air pollution is a global environmental and health concern, contributing to onset and deterioration of respiratory and cardiovascular diseases. As climate change and dependence on diminishing fossil fuel supplies have taken center stage in political and scientific debates, renewable carbon-neutral fuels like biodiesel receive increasing attention. The most common biodiesel within the European Union, rapeseed oil methyl ester (RME) is perceived to be a "green fuel", as it is sustainable and of biological origin, and therefore is often predicted to be less harmful to human health. Whilst replacing petrodiesel with biodiesel may have advantageous ecological impacts, consequences to respiratory health remained largely unexplored. The purpose of the current study is to evaluate whether inhalation of 100% RME biodiesel exhaust would result in an acute airway inflammatory response in healthy human subjects, as shown previously following exposure to petrodiesel exhaust.

Enrollment

15 patients

Sex

All

Ages

20 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Normal ECG

Normal Lung function

Normal Blood samples

Exclusion criteria

Smoking

Pre-existing metabolomic, respiratory and cardiovascular disease

Exposure to high levels of pollutants in occupation

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Triple Blind

15 participants in 2 patient groups

Filtered air exposure
Sham Comparator group
Description:
One hour exposure to filtered air during intermittent exercise in controlled chamber, 6 hours after exposure bronchoscopy is performed.
Treatment:
Other: Bronchoscopy
Biodiesel exhaust exposure
Experimental group
Description:
One hour exposure to biodiesel exhaust (generated at same running conditions as earlier studies with diesel exhaust at approximate particle matter concentration 300 mcg/m3) during intermittent exercise in controlled chamber. Six hours after exposure bronchoscopy is performed.
Treatment:
Other: Bronchoscopy

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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