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Air pollution is a global environmental and health concern, contributing to onset and deterioration of respiratory and cardiovascular diseases. As climate change and dependence on diminishing fossil fuel supplies have taken center stage in political and scientific debates, renewable carbon-neutral fuels like biodiesel receive increasing attention. The most common biodiesel within the European Union, rapeseed oil methyl ester (RME) is perceived to be a "green fuel", as it is sustainable and of biological origin, and therefore is often predicted to be less harmful to human health. Whilst replacing petrodiesel with biodiesel may have advantageous ecological impacts, consequences to respiratory health remained largely unexplored.
The purpose of the current study is to evaluate whether inhalation of 100% RME biodiesel exhaust would result in an acute airway inflammatory response in healthy human subjects, as shown previously following exposure to petrodiesel exhaust.
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Inclusion criteria
Normal ECG
Normal Lung function
Normal Blood samples
Exclusion criteria
Smoking
Pre-existing metabolomic, respiratory and cardiovascular disease
Exposure to high levels of pollutants in occupation
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Interventional model
Masking
15 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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