Pulmonary Fibrosis After Severe COVID-19 Pneumonia (SPIFFERO)

San Donato Group (GSD)

Status: Completed

Conditions: COVID-19; Pulmonary Fibrosis

Treatments: Radiation: Computed tomography

Study type: Observational

Funder types: Other

Identifiers

NCT06423560

CET 145-2024

Details and patient eligibility

About

Patients discharged after hospitalization for COVID-19 pneumonia were retrospectively selected by radiologically established criteria that at admission presented at chest computed tomography (CT) (i) normal lung parenchyma <50% of total lung volume; and/or (ii) area of lung consolidation > 10%. All At discharge and after 9 months, all subjects underwent cardiological evaluation, echocardiogram, pulmonary function tests (PFT) both atby 3 and by 12 months after discharge. Chest CT was performed by 12 months after discharge and chest CT. Specifically, the magnitude of pulmonary involvement between baseline and follow-up was considered the primary endpoint of this study. Secondary endpoints of the study were results of respiratory function testing, echocardiographic parametersparameters, and persistence of symptoms.

Enrollment: 61 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18
• Hospitalization for severe COVID-19 pneumonia
• Computed tomography during index hospitalization that showed: (i) normale lung parenchyma < 50% of total lung volume and/or (ii) parenchymal consolidation > 10%
• Cardiological and pneumological visit, echocardiography and pulmonary function test at 3 and 12 months from hospital discharge
• Computed tomography by 12 months from hospital discharge

Exclusion criteria

• Age < 18
• Absence of previously cited test.

Trial design

61 participants in 2 patient groups

Residual disease > 20% of the total lung volume was considered pathological at follow-up CT

Treatment:

Radiation: Computed tomography

Residual disease < 20% of the total lung volume was considered pathological at follow-up CT

Treatment:

Radiation: Computed tomography