Pulmonary Hemodynamics During Exercise - Research Network (PEX-NET)

Medical University of Graz

Status

Enrolling

Conditions

Pulmonary Circulation Diseases

Treatments

Diagnostic Test: assessment of pulmonary hemodynamics during exercise by right heart catheterization

Study type

Observational

Funder types

Other

Identifiers

NCT03954574

30-437 ex 17/18

Details and patient eligibility

About

The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.

Enrollment

1,500 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients (females and males; age: above 18yrs) with intermediate or high echocardiographic probability of PH and/or unexplained dyspnea, and/or associated conditions for PAH as clinical indication for RHC at rest and exercise
Written informed consent of participating subjects after being fully briefed (for prospective analysis)

Exclusion criteria

Patients with incomplete hemodynamic data at rest or exercise
Patients without sufficient follow-up data (information on survival / lung transplantation)
advanced tumour disease or other diseases with a short life expectancy, except pulmonary vascular diseases
advanced heart failure with pulmonary arterial wedge pressure (PAWP) > 18 mmHg at rest
uncontrolled systemic arterial hypertension (RR values > 160/100 mmHg at rest)
FEV1<50% predicted
TLC<60% predicted