Pulmonary Hypertension on Prognosis of Acute Myocardial Infarction Patients With Reduced Left Ventricular Function (STIMULATE)

Xi'an Jiaotong University

Status: Completed

Conditions: Acute Myocardial Infarction; Pulmonary Hypertension

Treatments: Other: This was an observational study, and no Intervention was given to the patients.

Study type: Observational

Funder types: Other

Identifiers

NCT06186713

XJTU1AF2023LSK-406

Details and patient eligibility

About

Pulmonary hypertension (PH) has a negative effect on acute myocardial infarction (AMI) patients and appears to be closely associated with reduced left ventricular function. However, its impact on AMI patients with reduced left ventricular function remains unclear. This retrospective study included AMI patients with reduced left ventricular function to investigate the prognostic value of PH in this specific type of patient. Meanwhile, a nomogram would be established basing on the identified independent risk factors, hoping to provide a novel risk stratification for them.

Enrollment: 4,784 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patients who were hospitalized for AMI with reduced left ventricular function at the First Affiliated Hospital of Jiaotong University from January 2018 to January 2022.

Exclusion criteria

• Myocardial infarction complicated by cardiac rupture.
• Significant pre-existing heart failure.
• Other comorbidities such as malignancy that may significantly affect prognosis.
• Incomplete clinical data.

Trial design

4,784 participants in 2 patient groups

Pulmonary hypertension (PH) group

Description:

The PH group comprised of patients with systolic pulmonary artery pressure (sPAP) ≥ 35mmHg measured by echocardiology.

Treatment:

Other: This was an observational study, and no Intervention was given to the patients.

Control group

Description:

The control group included patients with systolic pulmonary artery pressure (sPAP) \<35mmHg measured by echocardiology.

Treatment:

Other: This was an observational study, and no Intervention was given to the patients.