Pulmonary Rehabilitation in Patients Before Lung Transplantation (LTx)

Schön Klinik Berchtesgadener Land

Status: Completed

Conditions: Hypercapnia; Respiratory Insufficiency; Pre-Lung-Transplantation; COPD

Treatments: Other: interval training; Other: continuous endurance training

Study type: Interventional

Funder types: Other

Identifiers

NCT00962078

PRÄ-LTX-08022

Nr. 08022

Landesärztekammer Bayern

Ethikkommission

Details and patient eligibility

About

The purpose of this study is to study the effects of a complex pulmonary rehabilitation program on mobility measured by 6 minute walking distance (6MWD) and physical activity, measured via Dynaport and Actibelt Aktivitätsmonitor, dyspnoea (VAS), quality of life (HRQL (SF36, EuroQul)), anxiety and depression (HADS)and PaCO2-behavior under physical activity.

Enrollment: 71 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• pre-LTx (listed for lung-transplantation or currently undergoing evaluation)
• COPD Stadium IV GOLD
• α-1-Antitrypsin-deficiency-Emphysema
• respiratory Insufficiency
• oxygen therapy (LTOT)

Exclusion criteria

• serious Exacerbation (Symptoms longer than three days, change of therapy, e.i. antibiotics, steroids) during the last four weeks before rehabilitation
• clinical signs of manifest heart insufficiency
• acute coronar syndrome
• left heart insufficiency(EF < 40%)
• missing Compliance

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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71 participants in 2 patient groups

interval training

Other group

Description:

interval training in lung transplant candidates

Treatment:

Other: interval training

Continuous Training

Other group

Description:

continuous training in lung transplant candidates

Treatment:

Other: continuous endurance training