Pulmonary Rehabilitation in Patients With Fibrotic Interstitial Lung Disease

University of California San Francisco (UCSF)

Status

Terminated

Conditions

Fibrotic Interstitial Lung Disease

Treatments

Behavioral: Pulmonary Rehabilitation

Study type

Interventional

Funder types

Other

Identifiers

NCT00415272

H52476-29802-01

Details and patient eligibility

About

Our study aims to investigate the benefits of an outpatient pulmonary rehabilitation program in a population of subjects with fibrotic interstitial lung disease. Our hypothesis is that pulmonary rehabilitation will lead to improvements in quality of life, breathlessness, exercise capacity and pulmonary function in this patient population.

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

Restriction on pulmonary function testing (TLC <80%, FEV1/FVC ratio > predicted or DLCO < 80%)
Evidence of fibrosis on high resolution computed tomography of the chest.
Fibrosis on surgical lung biopsy if performed
Referral for pulmonary rehabilitation

Exclusion criteria

Participation in pulmonary rehabilitation in the past 24 months
Inability to complete 6 minute walk test or study questionnaires
Limitations other than dyspnea (e.g. arthritis) that affect ability to participate in pulmonary rehabilitation
Baseline 6 minute walk distance > 400 meters
Planned change in medication treatment for lung disease during the course of pulmonary rehabilitation
Ejection fraction known to be < 25%
Contraindications to pulmonary rehabilitation (clinically unstable, uncontrolled arrhythmia or hypertension, symptomatic or uncontrolled hypotension with systolic blood pressure of < 95, active angina, unexplained syncope or worsening dizziness, limiting orthopedic or neurological disorders, psychiatric impairment that inhibits cooperation in the program)
FEV1/FVC < 65%
Unable to provide informed consent