Pulsatile and Steady State Hemodynamics in Diastolic Heart Failure

Klinikum Wels-Grieskirchen

Status: Completed

Conditions: Diastolic Heart Failure

Study type: Observational

Funder types: Other

Identifiers

NCT00720525

EK 248

Details and patient eligibility

About

Over the past few years, there has been a growing appreciation that a large number of patients with heart failure have a relatively normal (or preserved) ejection fraction (NFNEF). Epidemiologically, HFNEF is most prevalent among elderly women, most of whom have hypertension, diabetes, or both and often coronary artery disease (CAD). Increased arterial stiffness and/or wave reflections have been described in the same patient groups. Therefore, the investigators speculate that pulsatile hemodynamics, representing arterial stiffness and/or arterial wave reflections, 1) may be altered in HFNEF patients, 2) this may contribute to pathophysiology of HFNEF, and 3) this may be used for the diagnosis of the syndrome.

Enrollment: 362 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• exertional dyspnea
• undergoing heart catheterization for diagnosis or exclusion of coronary artery disease
• normal EF (> 50%)

Exclusion criteria

• atrial fibrillation
• more than mild valvular heart disease
• pericardial disease
• no informed consent

Trial design

362 participants in 2 patient groups

1

Description:

Patients with diastolic heart failure

2

Description:

Patients without diastolic heart failure