Pulsatility Index, Vasomotor Reactivity and Leukoencephalopathy in Fabry Patients

National and Kapodistrian University of Athens

Status: Completed

Conditions: Fabry Disease

Treatments: Diagnostic Test: Transcranial Doppler (TCD) and Transcranial Color-Coded Duplex (TCCD) ultrasonography

Study type: Observational

Funder types: Other

Identifiers

NCT04577170

FD29092020

Details and patient eligibility

About

We hypothesize that Fabry disease - FD is associated with elevated vascular resistance induced by cerebral small-vessel disease, indicating increased distal resistance to blood flow. The findings of this study may be used as a precursor for neuroimaging manifestations related to stroke in FD patients.

Enrollment: 45 patients

Sex: All

Ages: 16 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Fabry disease diagnosis, genetically confirmed Age> 16 years

Exclusion criteria

Insufficient temporal bone window MRI contra-indication Inability to cooperate for breath-holding test Detection of atrial fibrillation Refuse to sing informed consent

Trial design

45 participants in 2 patient groups

Fabry disease

Treatment:

Diagnostic Test: Transcranial Doppler (TCD) and Transcranial Color-Coded Duplex (TCCD) ultrasonography

Healthy

Description:

age and sex matched

Treatment:

Diagnostic Test: Transcranial Doppler (TCD) and Transcranial Color-Coded Duplex (TCCD) ultrasonography