Pulse Pressure Variation Based Intraoperative Fluid Management Versus Traditional Fluid Management for Colonic Cancer Patients Undergoing Mass Resection and Anastomosis

Ain Shams University

Status: Completed

Conditions: Postoperative Complications; First Time to Gastrointestinal Motion; Serum Lactate; Length of the Hospital Stay; Intestinal Edema; Intraoperative Fluid Volume; Hemodynamics

Treatments: Other: conventional fluid management; Device: pulse pressure variation

Study type: Interventional

Funder types: Other

Identifiers

NCT05502835

IRB00006379 GUT OEDEMA

Details and patient eligibility

About

pulse pressure variation based intraoperative fluid therapy versus traditional fluid therapy for colonic cancer patients undergoing mass resection and anastomosis for maintaining adequate hydration without complications.

Full description

All Patients will be assigned randomly by using computerized program to one of the two equal groups. Patients will be (forty five patients per group):

Group A ;( control group) Forty five patients will do elective open colonic mass resection and anastomosis. Infusion of 6 ml/kg/hr. Ringer's solution.

Group B; Forty five patients will do elective open colonic mass resection and anastomosis. Infusion of 2 ml/kg/hr. Ringer's solution guided by pulse pressure variation.

Intraoperative fluid volume, hemodynamics, serum lactate and intestinal edema will be measured after induction of anesthesia and every hour till the end of the operation, length of the hospital stay, first time to gastrointestinal motion and postoperative complications are recorded.

Enrollment: 90 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists physical status (ASA-PS) I and II Patients.
• Patients scheduled for elective open colonic mass resection and anastomosis.

Exclusion criteria

• Serious cardiac arrhythmia.
• Peripheral artery disease.
• An ejection fraction below 30%.
• A pulmonary pathology.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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90 participants in 2 patient groups

conventional fluid management group

Experimental group

Description:

patients will do elective open colonic mass resection and anastomosis will receive Infusion of 6 ml/kg/hr. Ringer's solution.

Treatment:

Other: conventional fluid management

ppv group

Active Comparator group

Description:

patients will do elective open colonic mass resection and anastomosis. Infusion of 2 ml/kg/hr. Ringer's solution guided by pulse pressure variation.

Treatment:

Device: pulse pressure variation