Pulse Pressure Variation for Prediction of Fluid Responsiveness in Coronary Artery Disease Patients With Diastolic Dysfunction

Yonsei University

Status: Completed

Conditions: Fluid Responsiveness Predictability

Treatments: Drug: Fluid loading (Voluven)

Study type: Interventional

Funder types: Other

Identifiers

NCT01819571

1-2011-0056

Details and patient eligibility

About

The investigators hypothesized that predictability of pulse pressure variation (PPV) on fluid responsiveness would be reduced in patients with coronary disease who have diastolic dysfunction.

Enrollment: 66 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients older than 20 years
• scheduled for elective coronary artery bypass grafting
• normal diastolic function (E/E' < 8) or diastolic dysfunction (E/E' >15) according to preoperative Echocardiographic evaluation

Exclusion criteria

• arrythmia,
• reduced left ventricular function (ejection fraction < 40%)
• valvular heart disease requiring concomitant surgical correction
• pulmonary hypertension (mean pulmonary arterial pressure ≥30 mm Hg)
• peripheral arterial occlusive disease, pulmonary disease (asthma, chronic obstructive pulmonary disease, and lung resection)
• end-stage renal disease

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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66 participants in 2 patient groups

Normal diastolic function group

Experimental group

Treatment:

Drug: Fluid loading (Voluven)

Diastolic dysfunction group

Active Comparator group

Treatment:

Drug: Fluid loading (Voluven)