Pulse Pressure Variation Measured During Valsalva Maneuver to Predict Fluid Responsiveness Under Open-chest Condition

Samsung Medical Center

Status: Completed

Conditions: Thoracic Surgical Procedures; Sternotomy; Cardiac Surgical Procedures

Treatments: Other: Fluid loading; Procedure: Valsalva maneuver

Study type: Observational

Funder types: Other

Identifiers

NCT02457572

SMC 2014-07-005

Details and patient eligibility

About

Pulse pressure variation (PPV) is a well-known dynamic preload indicator to predict fluid responsiveness. However, its usefulness in open-chest conditions has been equivocal. The investigators evaluated whether PPV measured during Valsalva maneuver can predict fluid responsiveness after sternotomy.

Enrollment: 55 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients undergoing elective off-pump coronary arterial bypass grafting

Exclusion criteria

• Preoperative LV EF <= 35%
• Moderate or severe valvular heart disease
• Cardiac arrhythmia
• Intracardiac shunt
• Severe renal or liver disease
• Moderate to severe pulmonary hypertension (mean PAP > 35 mmHg)
• Patients with bullous lung disease or combined pneumothorax

Trial design

55 participants in 1 patient group

Valsalva maneuver

Description:

This is an observational study and as a diagnostic intervention, subjects in the study would receive valsalva maneuver. Valsalva maneuver was performed after sternotomy with the constant airway pressure of 30cmH2O for 2 breaths duration. The investigators perform this procedure to every patients and do not assign this intervention to the subjects of the study.

Treatment:

Procedure: Valsalva maneuver

Other: Fluid loading