Pulse Wave Velocity and Hemodynamic Response During Anesthesia Induction in Hypertensive Patients (AS)

Aydin Adnan Menderes University

Status: Completed

Conditions: Arterial Stiffness

Treatments: Procedure: Mobil-O-Graph PWA

Study type: Observational

Funder types: Other

Identifiers

NCT05155514

Arterial stiffness

Details and patient eligibility

About

Hypertension is a disease with increasing and serious complications all over the world. In particular, the incidence of hypertension increases with advancing age. Secondary problems that can be caused by hypertension include peripheral vascular diseases, arteriosclerosis, increased risk of heart attack and stroke. It is a measurement of pulse wave velocity (PWV), a non-invasive indicator of arterial stiffness. It is known that sudden hemodynamic changes that occur during the induction of anesthesia cause undesirable intraoperative and postoperative complications. It is known that arterial stiffness, which is more common in elderly patients, causes orthostatic hypotension in particular. For this reason, more hemodynamic instability may be seen in the general anesthesia procedure in elderly patients with increased arterial stiffness.

In our study, we aimed to investigate whether the hemodynamic changes observed during anesthesia induction in hypertensive elderly patients, whom we think have a high pulse wave velocity, are different from normotensive patients.

Enrollment: 139 patients

Sex: All

Ages: 50+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• According to the American Society of Anesthesiologists (ASA), physical condition I-II,
• Elective otolaryngology surgery with endotracheal intubation planned
• Patients aged 50 and over

Exclusion criteria

• Hypersensitivity to drugs
• Difficult intubation history
• Diabetes mellitus receiving insulin therapy
• Chronic renal failure or end-stage renal disease
• Heart failure (left ventricular ejection fraction ≤30%)
• Valve disease (moderate to severe)
• Atrial fibrillation

Trial design

139 participants in 2 patient groups

Group H

Description:

Hypertension group (Group H): * Patients with a previous diagnosis of hypertension * Patients receiving antihypertensive therapy * Systolic blood pressure (SBP) ≥140mmHg and/or diastolic blood pressure (DBP) ≥90mmHg

Treatment:

Procedure: Mobil-O-Graph PWA

Group N

Description:

Normotensive group (Group N): Other non-hypertensive patients

Treatment:

Procedure: Mobil-O-Graph PWA