Pulsed Dye Laser in Treating Patients With Post Radiation Dysphonia

Wake Forest University (WFU)

Status

Completed

Conditions

Stage I Laryngeal Cancer

Oral Complications of Radiation Therapy

Stage II Laryngeal Cancer

Treatments

Other: questionnaire administration

Procedure: laser therapy

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT02198131

P30CA012197 (U.S. NIH Grant/Contract)

IRB00011092

NCI-2014-01458 (Registry Identifier)

CCCWFU 98214 (Other Identifier)

Details and patient eligibility

About

This pilot trial studies pulsed dye laser in treating patients with post radiation dysphonia. Dysphonia, or vocal cord scarring, can include trouble with the voice when trying to talk, such as hoarseness, change in voice pitch, and poor voice quality, and it commonly happens after radiation therapy for laryngeal cancer. Pulsed dye laser may improve post radiation dysphonia.

Full description

PRIMARY OBJECTIVES:

I. To evaluate the use of pulsed dye laser in treatment of the dysphonia that commonly results after radiation therapy for laryngeal carcinoma.

OUTLINE:

Patients undergo pulsed dye laser monthly for three months.

After completion of study treatment, patients are followed up at 1, 3, and 6 months.

Enrollment

9 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients suffering from dysphonia after radiation therapy for glottic carcinoma will be included in the study
Patients will be included if their initial stage was T1 N0 M0 or T2 N0 M0

Exclusion criteria

Patients having previously undergone large surgical resections of the larynx or hypopharynx will be excluded
Patients fewer than 1 year out from completion of radiation therapy will be excluded
Patients with local disease recurrence would be excluded from the trial
Patients in whom the transnasal endoscope is poorly tolerated or patients in whom transnasal endoscopic laryngoscopy is contraindicated will be excluded